Optimising flow in a sensor channel NIR spectroscopy for in-line assay monitoring of a pharmaceutical suspension

Increasing accuracy of in-line suspension monitoring

In-line NIR (near infrared) spectroscopy was used to continuously monitor the concentraiton of the active pharmaceutical ingredient in a suspension. The sensor was mounted in a T-piece through which the suspension passed. The orginal design led to unstable measurements. CFD was used to optimise the system and improve the accuracy of this in-line monitoring.

Major findings

  • Thurbulence in the original channel led to unstable NIR measurements
  • Based on CFD a new design was proposed which significantly improved the accuracy
  • Understanding of both fluid dynamics and the process (eg NIR for in-line monitoring) led to an effective monitoring set-up